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MOTS-c

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c; 16-aa mitochondrial-derived peptide) · 5 min read

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA (MT-RNR1) region. It is offered as a lyophilized, HPLC-characterized reference material for in-vitro research into mitochondrial signaling and cellular energy-sensing pathways. This listing is for laboratory Research Use Only and is not for human or veterinary use.

Analytical identity

Supplied as a lyophilized powder at ≥98% (HPLC) purity. The peptide carries the canonical 16-residue sequence MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg), molecular formula C₁₀₁H₁₅₂N₂₈O₂₂S₂, and a monoisotopic/average molecular weight near 2174.6 g/mol (PubChem CID 146675088). Identity and purity are characterized by HPLC and mass spectrometry for use as an analytical reference standard.

Literature mechanism themes

In the research literature, MOTS-c is described as a mitochondrial-derived peptide that engages the AMPK energy-sensing pathway, reported in cell and tissue models to act through the folate–AICAR–AMPK axis. It is also studied for retrograde mitochondrial-to-nuclear signaling, including nuclear translocation under metabolic stress and modulation of Nrf2-linked antioxidant-response gene expression. These mechanisms are summarized here only as published research themes describing in-vitro and model-system observations.

Research context

MOTS-c serves as a model compound in mitochondrial-derived-peptide (MDP) biology, where investigators examine retrograde signaling, energy-sensing-pathway regulation, and metabolic-homeostasis signaling in cultured cells and tissue preparations. The material is intended solely as a characterized reference standard for such in-vitro and analytical work.

Handling and intended use

For Research Use Only (RUO). Not for human or veterinary use, diagnostic, or therapeutic application. As a lyophilized peptide, it is typically stored desiccated and protected from light at the supplier-recommended temperature; consult the certificate of analysis for lot-specific handling parameters.

Credible sources

Research context only. This article summarizes published in-vitro and pre-clinical research for scientific context. It is not a claim of efficacy or safety and does not constitute medical, usage, or dosing guidance. Helix Reagents products are Research Use Only and not for human or veterinary use.