CJC-1295 / Ipamorelin (no DAC) research library

This catalog item is a two-component research blend (catalog strength 20 mg) supplied as a lyophilized powder for Research-Use-Only applications. It pairs CJC-1295 without DAC (Mod GRF 1-29), a tetrasubstituted synthetic analog of growth-hormone-releasing hormone GHRH(1-29), with Ipamorelin, a pentapeptide selective agonist of the growth-hormone-secretagogue (ghrelin) receptor. Because it is a blend, no single CAS, molecular formula, or molecular weight applies; each component is characterized separately by sequence and analytical identity. The material is intended as a characterized reference standard for in-vitro and laboratory investigation only.

Component identity

CJC-1295 without DAC (Mod GRF 1-29) is a 29-residue GHRH(1-29) analog with substitutions at positions 2, 8, 15 and 27 (including D-Ala at position 2) reported in the literature to confer resistance to enzymatic cleavage; molecular formula C152H252N44O42 (~3367.9 g/mol). Ipamorelin is a pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2 (C38H49N9O5; ~711.85 g/mol; CAS 170851-70-4; PubChem CID 9831659), incorporating the non-natural residues aminoisobutyric acid (Aib) and D-2-naphthylalanine (D-2-Nal).

Mechanism themes in the literature

The two components are described in published work as acting on distinct receptors: the CJC-1295 (no DAC) component is characterized as a GHRH-receptor (GHRH-R) agonist, while the Ipamorelin component is characterized as a selective agonist at the growth-hormone-secretagogue receptor (GHS-R1a / ghrelin receptor). The pairing is of interest as a model for studying two complementary signaling nodes of the somatotrope axis in vitro.

Research context (RUO)

Supplied strictly as a Research-Use-Only reference material for in-vitro and analytical work — for example receptor-pharmacology and GPCR signaling assays, structure-activity studies of peptide secretagogue analogs, and HPLC/MS-based identity and purity characterization. Not for human or veterinary use; not a drug, food, or cosmetic.

Handling and analytical identity

Provided as a lyophilized powder at ≥98% (HPLC) purity. As a multi-component blend it carries no single CAS, molecular formula, or molecular weight; identity is established per component by amino-acid sequence and orthogonal HPLC / mass-spectrometric characterization.

Credible sources

Research context only. This article summarizes published in-vitro and pre-clinical research for scientific context. It is not a claim of efficacy or safety and does not constitute medical, usage, or dosing guidance. Helix Reagents products are Research Use Only and not for human or veterinary use.