MOTS-c
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c; 16-aa mitochondrial-derived peptide) · ≥98% (HPLC)
MOTS-c is a 16-amino-acid mitochondrial-derived peptide supplied as a characterized reference material for in-vitro mitochondrial-signaling and metabolic-pathway research. Research Use Only.
- Why researchers study it
- MOTS-c is studied as a model mitochondrial-derived peptide for investigating retrograde mitochondrial-to-nuclear signaling and the regulation of cellular energy-sensing pathways in cell and tissue models.
- Mechanism themes in research
- AMPK energy-sensing pathway modulation (Folate–AICAR–AMPK axis)Retrograde mitochondrial-to-nuclear signaling and nuclear translocation under metabolic stressNrf2/antioxidant-response gene-expression regulationGlucose-metabolism and GLUT4-translocation signaling in skeletal-muscle cell models
- What the evidence does not establish
- Published references are in-vitro or pre-clinical and describe research context only. They do not establish safety, efficacy, or any outcome in humans or animals, and Helix makes no such claims.
- Quality markers
- ≥98% (HPLC)MS identityLot COACold-chain
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA (MT-RNR1) region. It is offered as a lyophilized, HPLC-characterized reference material for in-vitro research into mitochondrial signaling and cellular energy-sensing pathways. This listing is for laboratory Research Use Only and is not for human or veterinary use.
Analytical identity
Supplied as a lyophilized powder at ≥98% (HPLC) purity. The peptide carries the canonical 16-residue sequence MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg), molecular formula C₁₀₁H₁₅₂N₂₈O₂₂S₂, and a monoisotopic/average molecular weight near 2174.6 g/mol (PubChem CID 146675088). Identity and purity are characterized by HPLC and mass spectrometry for use as an analytical reference standard.
Literature mechanism themes
In the research literature, MOTS-c is described as a mitochondrial-derived peptide that engages the AMPK energy-sensing pathway, reported in cell and tissue models to act through the folate–AICAR–AMPK axis. It is also studied for retrograde mitochondrial-to-nuclear signaling, including nuclear translocation under metabolic stress and modulation of Nrf2-linked antioxidant-response gene expression. These mechanisms are summarized here only as published research themes describing in-vitro and model-system observations.
| Full name | MOTS-c (mitochondrial open reading frame of the 12S rRNA-c; 16-aa mitochondrial-derived peptide) |
| Research theme | Mitochondrial & energy |
| CAS number | |
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.6 g/mol |
| Purity | ≥98% (HPLC) |
| Physical form | Lyophilized powder |
| Storage | −20 °C, desiccated, protected from light |
Sequence
Reported research areas
- Mitochondrial-derived peptide (MDP) biology
- Cellular energy-sensing and AMPK pathway studies
- Metabolic-homeostasis signaling in vitro
- Mitochondrial retrograde-signaling and gene-expression research
Credible sources
- PubChem — MOTS-c (CID 146675088)
- PubMed — MOTS-c mitochondrial-derived peptide literature
- PMC — MOTS-c: effects and mechanisms in stress, metabolism and aging
COA with every lot
Each MOTS-c lot is characterized by reversed-phase HPLC for purity and by mass spectrometry for identity, then documented in a per-lot Certificate of Analysis. Unique lot numbers tie the vial back to its synthesis batch and analytical data.
- RP-HPLC purity result (≥98% (HPLC))
- Mass-spectrometry identity confirmation
- Appearance, molecular weight, and storage
- Lot number and testing status
Specimen Certificate of Analysis
| Product | MOTS-c (reference) |
| Lot | HXR-2406-101 |
| Purity (RP-HPLC) | 98%+ |
| Identity (MS) | Confirmed · 2174.6 g/mol |
| Appearance | Lyophilized powder |
| Storage | −20 °C, desiccated |
Representative document. Each lot has its own COA — these are quality documents, not medical claims.